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Abstract. Guided by X-ray crystallography, we have extended the structure-activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B ...
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Jun 24, 2022 · Ertiprotafib is a phosphotyrosine (pTyr) monocarboxylic acid mimetic developed by Wyeth and the first PTP1B inhibitor to be tested in clinical ...
A synthetic small molecule that selectively inhibits PTP1B action is expected to have similar beneficial effects in type 2 diabetic and obesity patients. Two ...
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Abstract. Guided by X-ray crystallography, we have extended the structure–activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B ...
Jun 25, 2003 · Protein tyrosine phosphatase (PTPase) 1B (PTP1B) has been implicated as a major negative regulator of the insulin and leptin signaling pathway.
Jan 11, 2024 · The most noticeable improvement was shown by 1XBO, an isoxazole carboxylic acid inhibitor [55] . Compared to its X-ray conformation (Figure 6A), ...
Abstract: Protein tyrosine phosphatase (PTPase) 1B (PTP1B) has been implicated as a key negative regulator of both insulin and leptin signaling cascades.
Protein tyrosine phosphatase 1B (PTP1B) is an attractive target for treating cancer, obesity, and type 2 diabetes. In our work, the way of combined ligand- ...
Rational design, synthesis, and structure–activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B ...
Protein tyrosine phosphatase (PTPase) 1B (PTP1B) has been implicated as a key negative regulator of both insulin and leptin signaling cascades.